阿部研究室

山形大学大学院理工学研究科 バイオ化学工学専攻
〜計測と生物の融合技術で生命の神秘を探る〜


研究論文

2010年
  1. Kimura N., Tsunoda T., Iuchi Y., Abe H., Totsukawa K., Fujiii J. (2010) Intrinsic oxidative stress causes either two-cell arrest or cell death depending on developing stages of the embryos from SOD1-deficient mice. Molecular Human Reproduction, 16:441-451.
  2. Sugimura S., Yokoo M., Yamanaka K. Kawahara M., Wakai T., Nagai T., Abe H., Sato E. (2010) Anomalous oxygen consumption in porcine somatic cell nuclear transfer embryos. Cellular Reprogramming, 12 (4):463-474.
  3. Goto K., Koike M., Kumasako Y., Utsunomiya T., Araki Y., Abe H. (2010) Evaluating the safety and quality of human embryos with measurement of oxygen consumption by scanning electrochemical microscopy. Journal of Fertilization and Implatation, 27 (1), 53-58.
  4. Sakagami N., Yamamoto T., Akiyama K., Nakazawa Y., Kojima N., Nishida K., Yokomizo S., Takagi Y., Abe H., Suzuki C., Yoshioka K. (2010) Viability of porcine embryos after vitrification using water-soluble pullulan fims. J. Reprod. Dev., 56 (2):279-284.
  5. Yamashiro H., Toyomizu M., Kikusato M., Toyama N., Sugimura S., Hoshino Y., Abe H., Moisyadi S., Sato E. (2010) Lactate and adenosine triphosphate in extender enhance the cryosurvival of rat epididymal sperm. J. Am. Assoc. Lab. Anim. Sci., 49:160-166.
2009年
  1. Kyono K., Nakajo Y., Nishinaka C., Hattori H. Kyoya T., Ishikawa T., Abe H., Araki Y. (2009) A birth from the transfer of a single vitrified-warmed blastocyst using ICSI with calcium ionophore oocyte activation in a globozoospermic patient. Fertil. Steril., 91: e7-e11.
  2. Shiku H., Yamakawa T., Nashimoto Y., Takahashi Y., Torisawa Y., Yasukawa T., Ito-Sasaki T., Yokoo M., Abe H., Kambara H., Matsue T. (2009) A microfluidic dual capillary probe to collect mRNA from adherent cells and spheroids. Anal. Biochem., 385: 138-142.
  3. Murakawa H., Aono N., Tanaka T., Kikuchi H., Yoshida H., Yoshida H., Yokoo M., Abe H. (2009) Morphological evaluation and measurement of the respiration activity of cumulus-oocyte complexes to assess oocyte quality. J. Mamm. Ova Res., 26: 32-41.
  4. Goto M., Abe H., Ito-Sasaki T., Goto M., Inagaki A., Ogawa N., Fujimori K., Kurokawa Y., Matsue T., Satomi S. (2009) A novel predictive method for assesing the quality of isolated pancreatic islets using a scanning electrochemical microscopy. Transplantation Proc., 41:311-313.
2008年
  1. Ulloa Ulloa C.M., Yoshizawa M., Yamashita A., Hama S., Mitsui A., Hashi C., Abe H., Hoshi H., Fukui E., Matsumoto H. (2008) Blastocyst production from in vitro-produced Day-2 bovine embryos classified by cleavage stage, and cytogenetical of the resultant Day-8 blastocysts. J. Reprod. Dev., 54: F465-474.
  2. Hirobe T., Ishizuka K., Ogawa S., Abe H. (2008) Mitochondria are well developed in pink-eyed dilution melanoblasts in the neonatal mouse epidermis. Zool. Sci., 25: 1057-1065.
  3. Yokoo M., Kimura N., Abe H., Sato E. (2008) Influence of hyaluronan accumulation during cumulus expansion on in vitro porcine oocyte maturation. Zygote, 16: 309-314 .
  4. Abe H., Hoshi H. (2008) Morphometric and ultrastructural changes in ciliated cells of the oviductal epithelium in prolific Chinese Meishan and Large White pigs during the estrous cycle. Reprod. Domest. Anim., 43: 66-73.
  5. Utsunomiya T., Goto K., Nasu M., Kumasako Y., Araki Y., Yokoo M., Itoh-Sasaki T., Abe H. (2008) Evaluating the quality of human embryos with a measurement of oxygen consumption by scanning electrochemical microscopy, J. Mamm. Ova Res., 25: F2-7.
  6. Abe H., Yokoo M., Itoh-Sasaki T., Nasu M., Goto K., Kumasako Y., Araki Y., Shiku H., Matsue T., Utsunomiya T. (2008) Measurement of the respiratory activity of single human embryos by scanning electrochemical microscopy. Trans. of MRS-J, 33 (3): 759-762.
  7. Yokoo M., Ito-Sasaki T., Shiku H., Matsue T., Abe H. (2008) Multiple analysis of respiratory activity in the identical oocytes by applying scanning electrochemical microscopy. Trans. of MRS-J, 33 (3): 763-766.
2007年
  1. Nashimoto Y., Takahashi Y., Yamakawa T., Torisawa Y., Yasukawa T., Ito-Sasaki T., Yokoo M., Abe H., Shiku H., Kambara H., Matsue T. (2007) Analysis of mRNA from single adherent cells and spheroids collected using fast electrical lysis. Anal. Chem., 79: 6823-6830.
  2. Hirobe T., Abe H., Wakamatsu K., Ito S, Kawa Y., Soma Y., Mizoguchi M. (2007) Excess tyrosine rescues the reduced activity of proliferation and differentiation of cultured recessive yellow melanocytes derived from neonatal mouse epidermis. Eur. J. Cell Biol., 86: 315-330.
  3. Wu C.-C., Saito T., Yasukawa T., Shiku H., Abe H., Hoshi H., Matsue T. (2007) A microfluidic chip integrated with amperometric detector array for in situ estimating oxygen consumption characteristics of single bovine embryo. Sens. Actuat. B, 125: 680-687.
  4. Abe H., Hoshi H. (2007) Regional and cyclic variations in the ultrastructural features of secretory cells in the oviductal epithelium of the Chinese Meishan pig. Reprod. Domest. Anim., 42: 292-298.
  5. Hirobe T., Abe H. (2007) Changes of melanosome morphology associated with the differentiation of epidermal melanocytes in slaty mice. Anatomical Record, 290: 981-993.
  6. Hirobe T., Abe H. (2007) Excess tyrosine restores affected morphology and maturation of melanosomes by the murine slaty mutation . Zoological Science , 24: 338-345.
  7. Yokoo M., Shimizu T., Kimura N., Sri Tunjung W.A., Matsumoto H., Abe H., Sasada H., Rodriguez-Martinez H., Sato E. (2007) Role of hyaluronan receptor CD44 during in vitro maturation in pigs. J. Reprod. Dev., 53: 263-270.
  8. Abe H. (2007) A non-invasive and sensitive method for measuring cellular respiration with a scanning electrochemical microscopy to evaluate embryo quality. J. Mamm. Ova Res., 24: F70-78.
2006年
  1. 青柳重夫、内海陽介、松平昌昭、山田弘、甲地優志、珠玖仁、阿部宏之、星宏良、末永智一 (2006)呼吸量測定によるウシ体外培養胚の品質評価と半自動計測装置の開発 、分析化学 、55(11):847-854 .
  2. Saito T., Wu C.-C., Shiku H., Yasukawa T., Yokoo M., Sasaki T., Abe H., Hoshi H., Matsue T. (2006) Oxygen consumption of cell suspension in a poly(dimethlsiloxane) (PDMS) microchannel estimated by scanning electrochemical microscopy. Analyst, 131: 1006-1011.
  3. Hirobe T., Abe H. (2006) The murine slaty mutation affects the morphology and maturation of melanosomes in the mouse melanocytes. Pigment Cell Res., 19: 454-459.
  4. Shiku H., Saito T., Wu C.-C., Yasukawa T., Yokoo M., Abe H., Matsue T., Yamada H. (2006) Oxygen permeability of surface-modified poly (dimethylsiloxane) characterized by scanning electrochemical microscopy. Chemistry Letters, 35:234-235.
  5. Abe H., Shiku H., Yokoo M., Aoyagi S., Moriyasu S., Minamihashi A., Matsue T., Hoshi H. (2006) Evaluating the quality of individual embryos with a non-invasive and highly sensitive measurement of oxygen consumption by scanning electrochemical microscopy . J. Reprod. Dev., 52 (Suppl.): S55-S64.
2005年
  1. Sasaki T., Watanabe A., Takayama-Watanabe E, Suzuki M., Abe H., Onitake K. (2005) Ordered progress of spermiogenesis to the fertilizable sperm of the medaka fish,Oryzias latipes, in cell culture. Dev. Growth Differ., 47: 87-97.
  2. Agung B., Otoi T., Abe H., Hoshi H., Murakami M., Karja N.W.K., Murakami M.K., Wongsrikeao P., Watari H., Suzuki T. (2005) Relationship between oxygen consumption and sex of bovine in vitro fertilized embryos. Reprod. Dom. Anim ., 40: 51-56.
  3. Shiku H., Torisawa Y., Takagi A., Aoyagi S., Abe H., Hoshi H., Matsue T. (2005) Metabolic and enzymatic activity of individual cells, spheroids, and embryos as a function of the sample size. Sensors and Actuators B, 108: 597-602.
2004年
  1. Araki Y., Yoshizawa M., Abe H., Murase Y., Araki Y. (2004) Use of mouse oocytes to evaluate the ability of human sperm to activate oocytes after failure of activation by intracytoplasmic sperm injection. Zygote, 12: 111-116.
  2. Shiku H., Shiraishi T., Aoyagi S., Utsumi Y., Matsudaira M, Abe H., Hoshi H., Kasai S., Ohya H., Matsue T. (2004) Respiration activity of single bovine embryos entrapped in cone-shaped microwell monitored by scanning electrochemical microscopy. Analytica Chimica Acta, 522: 51-58.
  3. Abe H., Shiku H., Aoyagi S., Hoshi H. (2004) In vitro culture and evaluation of embryos for production of high quality bovine embryos. J. Mamm. Ova Res., 21: 22-30 .
2003年
  1. Kumasako Y., Utsunomiya T., Abe H., Araki Y. (2003) Influence of the Fallopian epithelial cells growing in vitro culture by infertile aspects. Japanese Journal of Fertility and Sterility, 48: 41-47. (In Japanese)
  2. Abe H., Hoshi H. (2003) Evaluation of bovine embryos produced in high performance serum-free media. Journal of Reproduction and Development, 49: 181-192 .
2002年
  1. Itoh T., Kacchi M., Abe H., Hoshi H. (2002) High recovery from successful cryopreservation of bovine small preantral follicles embedded within collagen gels. Tissue Culture Research Communications (The Journal of Experimental & Applied Cell Culture Research), 21: 109-119.
  2. Itoh T., Kacchi M., Abe H., Sendai Y., Hoshi H. (2002) Growth, antrum formation and estradiol production of bovine preantral follicles cultured in a serum-free medium. Biology of Reproduction, 67: 1099-1105.
  3. Abe H., Matsuzaki S., Hoshi H. (2002) Ultrastructural differences in bovine morulae classiifed as high and low qualities by morphological evaluation. Theriogenology, 57: 1273-1283.
  4. Abe H., Yamashita S., Satoh T., Hoshi H. (2002) Accumulation of cytoplasmic lipid droplets in bovine embryos and cryotolerance of embryos developed in different culture systems using serum-free or serum-containing media. Molecular Reproduction and Development, 61: 57-66.
  5. 阿部宏之、珠玖 仁、星 宏良(2002) ウシ胚におけるミトコンドリアの形態変化と胚の品質評価、日本胚移植学雑誌、24 (1): 19-27.
2001年
  1. Hirobe T., Wakamatsu K., Ito S., Abe H., Kawa Y., Mizoguchi M. (2001) Stimulation of the proliferation and differentiation of mouse pink-eyed dilution epidermal melanocytes by excess tyrosine in serum-free primary culture. Journal of Cellular Physiology, 191: 162-172.
  2. Shiku H., Shiraishi T., Ohya H., Matsue T., Abe H., Hoshi H., Kobayashi M. (2001) Oxygen consumption of single bovine embryos probed with scanning electrochemical microscopy. Analytical Chemistry, 73: 3751-3758.
  3. Hoshi H., Yamashita S., Abe H., Goto T (2001) In vitro maturation, fertilization of bovine oocytes and embryo culture in a serum-free medium. Asian-Aust. J. Anim. Sci., 14: 38-42.
2000年
  1. Shiku H., Shiraishi T., Ohya H., Matsue T., Abe H., Hoshi H., Kobayashi M. (2000) Monitoring activity of living cells entraped in a membrane-sealed microcapillary with scanning electrochemical microscopy . Electrochemistry , 68: 890-892.
  2. Hirobe T., Abe H. (2000) ACTH4-12 is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture. Journal of Experimental Zoology, 286: 632-640.
  3. Abe H., Yamashita S., Sata R., Tsujii H., Satoh T., Hoshi H. (2000) Culture systems for efficient production of high quality bovine embryos developed from in vitro-matured and -fertilized oocytes. -Quality evaluations of bovine embryos cultured in different culture systems using serum-free or serum-containing media-. Tissue Culture Research Communications (The Journal of Experimental & Applied Cell Culture Research), 19: 17-27.
1999年
  1. Abe H., Onodera M., Sugawara S., Satoh T., Hoshi H. (1999) Ultrastructural features of the goat oviductal secretory cells at follicular and luteal phases of the oestrous cycle. Journal of Anatomy, 195: 515-521.
  2. Abe H., Yamashita S., Itoh T., Satoh T., Hoshi H. (1999) Ultrastructure of bovine embryos developed from in vitro-matured and -fertilized oocytes: comparative morphological evaluation of embryos cultured either in serum-free medium or serum-supplemented medium. Molecular Reproduction and Development, 53: 325-335.
  3. Abe H., Otoi T., Tachikawa S., Yamashita S., Satoh T., Hoshi H. (1999) Fine structure of bovine morulae and blastocysts in vivo and in vitro. Anatomy and Embryology, 199: 519-527.
  4. Sata R., Tsujii H., Abe H., Yamashita S., Hoshi H. (1999) Fatty acid composition of bovine embryos cultured in serum-free and serum-containing medium during early embryonic development . Journal of Reproduction and Development, 45: 97-103.
  5. Yamashita S., Abe H., Itoh T., Satoh T., Hoshi H. (1999) A serum-free culture system for efficient in vitro production of bovine blastocysts with improved viability after freezing and thawing. Cytotechnology, 31: 123-131.
  6. Hirobe T., Abe H. (1999) Genetic and epigenetic control of the proliferation and differentiation of mouse epidermal melanocytes in culture. Pigment Cell Research, 12: 147-163.
  7. Hoshi H., Satoh T., Yamashita S., Abe H., Sata R., Tsujii H., Goto T. (1999) Production and embryo transfer of preimplantation bovine embryos cultured in serum-free medium. Comparative evaluation of developmental ability and quality of embryos obtained in serum-free and serum-supplemented medium . Tissue Culture Research Communications (The Journal of Experimental & Applied Cell Culture Research), 18: 163-172.
1998年
  1. Abe H., Satoh T., Hoshi H. (1998) Primary modulation by oestradiol of the production of an oviduct-specific glycoprotein by the epithelial cells in the oviduct of newborn golden hamsters. Journal of Reproduction and Fertility, 112: 157-163.
1997年
  1. Abe H., Hoshi H. (1997) Bovine oviductal epithelial cells: their cell culture and applications in studies for reproductive biology . Cytotechnology, 23: 171-183.
1996年
  1. Abe H. (1996) Immunocytochemical evidence that a specialized region of the rat oviduct secretes an oviductal glycoprotein. Journal of Anatomy, 188: 333-339.
  2. Abe H. (1996) The mammalian oviductal epithelium: regional variations in cytological and functional aspects of the oviductal secretory cells. Histology and Histopathology, 11: 743-768.
1995年
  1. Abe H., Sendai Y., Satoh T., Hoshi H. (1995) Bovine oviduct-specific glycoprotein: A potent factor for the maitenance of the viability and motility of bovine spermatozoa in vitro. Molecular Reproduction and Development , 42: 226-232.
  2. Abe H., Onodera M., Sugawara S. (1995) Immunological detection and characterization of an estrus-associated antigen in the goat oviduct. Journal of Experimental Zoology, 272: 134-141.
  3. Satoh T., Abe H., Sendai Y., Iwata H., Hoshi H. (1995) Biochemical characterization of bovine oviduct specific sialo-glycoprotein sustain sperm viability in vitro. Biochimica et Biophysica Acta, 1266: 117-123.
  4. Abe H., Sendai Y., Satoh T., Hoshi H. (1995) Secretory products of bovine oviductal epithelial cells support the viability and motility of bovine spermatozoa in culture in vitro. Journal of Experimental Zoology, 272: 654-661.
1994年
  1. Abe H. (1994) Regional variations in the ultrastructural features of secretory cells in the rat oviductal epithelium. Anatomical Record, 240: 77-85.
  2. Sendai Y.,Abe H., Kikuchi M., Satoh T., Hoshi H. (1994) Purification and molecular cloning of bovine oviduct-specific glycoprotein. Biology of Reproduction, 50: 927-934.
  3. Abe H, Kinoh H, Suzuki N (1994) Seasonal variations in the production of the egg-jelly macomolecule, a fucose sulfate glycoconjugate,by the accessory cells in the ovary of the sea urchin Hemicentroutus pulcherrimus . Roux's Archives of Developmental Biology, 203: 402-410.
1993年
  1. Abe H., Numazawa C., Abe M., Onodera M., Katsumi A. (1993) Immunocytochemical localization of oviduct-specific glycoproteins in the oviductal epithelium from cows at follicular and luteal phases. Cell and Tissue Research, 274: 41-47.
  2. Abe H., Abe M. (1993) Immunological detection of an oviductal glycorpteins in the rat. Journal of Experimental Zoology, 266: 328-335.
  3. Abe H., Numazawa C., Abe M., Hoshi H., Oikawa T. (1993) Production and characterization of monoclonal antibodies specific for bovine oviductal glycoproteins. Journal of Experimental Zoology, 265: 77-83.
  4. Abe H., Oikawa T. (1993) Observations by scanning electron microscopy of oviductal epithelial cells from cows at follicular and luteal phases. Anatomical Record, 235: 399-410.
  5. Abe H., Oikawa T. (1993) Effects of estradiol and progesterone on the cytodifferentiation of epithelial cells in the newborn golden hamster oviduct. Anatomical Record, 235: 390-398.
1992年
  1. Abe H., Kinoh H., Oikawa T., Suzuki N. (1992) The egg-jelly macromolecule, a fucose sulfate glycoconjugate, originates from the accessory cells of the ovary in the sea urchin Hemicentrotus pulcherrimus . Roux's Archives of Developmental Biology, 201: 179-189.
  2. Abe H., Oikawa T. (1992) Examination by scanning electron microscopy of oviductal epithelium of the prolific Chinese Meishan pig at follicular and luteal phases. Anatomical Record, 233: 399-408.
  3. Abe H., Ookata K., Abe M., Oikawa T. (1992) Immunological characterization of oviductal glycoproteins associated with the zona pellucida of the golden hamster egg. Journal of Experimental Zoology, 262: 209-218.
1991年
  1. Abe H., Oikawa T. (1991) Regional differences in the ultrastructural features of secretory cells in the golden hamster oviductal epithelium. Journal of Anatomy, 175: 147-158.
  2. Abe H., Oikawa T. (1991) Immunocytochemical localization of an oviductal zona pellucida glycoprotein in the oviductal epithelium of the golden hamster. Anatomical Record, 229: 305-314.
1900年
  1. Abe H., Oikawa T. (1990) Ultrastructural evidence for an association between an oviductal glycoprotein and the zona pellucida of the golden hamster egg. Journal of Experimental Zoology, 256: 210-221.
  2. Abe H., Oikawa T. (1990) Study of the differentiation of secretory cells in the oviductal epithelium by use of a monoclonal antibody. Journal of Experimental Zoology, 254: 97-106.
1989年
  1. Abe H., Oikawa T. (1989) Differentiation of the golden hamster oviduct epithelial cells during postnatal development: an electron microscopic study . Journal of Experimental Zoology, 252: 43-52.
1986年
  1. Abe H., Aizu S., Takeuchi T. (1986) Establishment of a cultured melanocyte clone from albino mouse . In: Structure and Function of Melanin . Ed. Jimbow K , Fuji-shoin , Sapporo, Vol. 3, pp. 69-74.
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